Prostate Cancer Analysis Toulouse Near Me

4worldlovers:
The CRCT leads an integrated approach between research, care and teaching, in a transversal and multidisciplinary logic.

Gene dysfunction is a hallmark of cancer. At the CRCT, we aim to discover how this process occurs. Several molecular oncogenic mechanisms are studied by our teams, including cancer cell signaling, genetic instability, gene expression, interconnection between cancer cells and the tumor microenvironment, bioenergetics…

We have set up research axes to explore the molecular complexity of cancer cells and tumor diversity, and we combine the strengths of our research teams to study the different aspects of cell transformation: our goal is to put together all the pieces of the “puzzle” that is cancer, in order to understand what initiates it and makes it progress.

The objective is to federate researchers, clinicians, engineers, technicians and students of the CRCT in order to share a multidisciplinary expertise with the common goal of understanding and targeting the autonomous and non-autonomous mechanisms of cancer oncogenic pathways.

CRCT researchers are exploring the mechanisms of deregulation of RNAs, key players in the control of gene expression, and their role in altering the cellular landscape that can lead to cancer initiation, progression, invasion and metastasis.

4worldlovers:
The team led by Christel Vérollet and Renaud Poincloux is awarded the “Equipe FRM” label to launch its research project on the biology of macrophages

Macrophages are innate immune cells that are present in all tissues to maintain immune surveillance and tissue homeostasis. However, in

The IPBS-Toulouse launches its annual call for the recruitment of new group leaders. As a leading research institute of the


Jean-Philippe Girard, Senior Research Director at Inserm, ranks among the world’s most cited scientists in the prestigious ‘Highly Cited Researchers


IP6, inositol hexaphosphate or phytic acid, is a product of cellular metabolism that binds to numerous proteins whose functions it

Dr. Julie Pannequin - Impact of tumor heterogeneity and plasticity on relapse in colorectal cancer

Dr. Julie Magarian Blander - Harnessing innate immunity and inflammasome in vaccines and cancer therapy

Pinilla et al. (2023) EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. J Exp Med 220(10): e20230104

Mascarau et al. (2023) Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells. J Cell Biol 222: e202205103

Viljoen*, Vercellone* et al. (2023) Nanoscale clustering of mycobacterial ligands and DC-SIGN host receptors are key determinants for pathogen recognition. Sci Adv 9(20): eadf9498

Seif-El-Dahan*, Kefala-Stavridi*, Frit*, Hardwick* et al. (2023) PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv 9(22): eadg2834

Voisinne*, Locard-Paulet* et al. (2022) Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination. Nat Immunol 23:1355-1364

Boudehen*, Faucher* et al. (2022) Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms. Nat Commun 13: 4731

Mosquera-Restrepo et al. (2022) A M. tuberculosis fingerprint in human breath allows tuberculosis detection. Nat Commun 13: 7751

Planès*, Pinilla*, Santoni*, Hessel*, Passemar* et al. (2022) Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell 82: 2385-2400.e9

Asrir*, Tardiveau*, Coudert*, Laffont*, Blanchard* et al. (2022) Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy. Cancer Cell 40: 318-334.e9

Demange*, Joly*, Marcoux* et al. (2022) SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species. Elife 11: e73913

Kefala-Stavridi*, Gontier*, Morin*, Frit* et al. (2023) Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res Oct 23:gkad863

The IPBS is a joint research center of the CNRS and the University of Toulouse. Occupying 12,000 m2 in the heart of the main campus of the University of Toulouse III-Paul Sabatier, which offers high-level multidisciplinary training in the fields of science, health and engineering, the IPBS is part of one of the most important scientific research poles in health and biological sciences in France.